|
KMID : 1100720210410010077
|
|
Annals of Laboratory Medicine
2021 Volume.41 No. 1 p.77 ~ p.85
|
|
|
Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population
|
|
Zou Yutong
Wang Danchen
Cheng Xinqi
Ma Chaochao
Lin Songbai
Hu Yingying
Yu Songlin
Xia Liangyu
Li Honglei
Yin Yicong
Liu Huaicheng
Zhang Dianxi
Zhang Kui
Lian Xiaolan
Xu Tengda
Qiu Ling
|
|
|
Abstract
|
|
|
Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thyroid-associated hormones and evaluated the prevalence of thyroid diseases in China.
Methods: After excluding outliers based on the results of ultrasound screening, thyroid antibody tests, and the Tukey method, the medical records of 20,303 euthyroid adults, who visited the Department of Health Care at Peking Union Medical College Hospital from January 2014 to December 2018, were analyzed. Thyroid-associated hormones were measured by the Siemens Advia Centaur XP analyzer. The RIs for thyroid-associated hormones were calculated according to the CLSI C28-A3 guidelines, and were compared with the RIs provided by Siemens. The prevalence of thyroid diseases over the five years was evaluated and compared using the chi-square test.
Results: The RIs for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were 0.71?4.92 mIU/L, 12.2?20.1 pmol/L, 3.9?6.0 pmol/L, 65.6?135.1 nmol/L, and 1.2?2.2 nmol/L, respectively. The RIs of all hormones except TT4 differed significantly between males and females. The RIs of TSH increased with increasing age. The prevalence of overt hypothyroidism, overt hyperthyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was 0.5% and 0.8%, 0.2% and 0.6%, 3.8% and 6.1%, and 3.3% and 4.7% in males and females, respectively, which differed from those provided by Siemens.
Conclusions: Sex-specific RIs were established for thyroid-associated hormones, and the prevalence of thyroid diseases was determined in the Chinese population.
|
|
|
KEYWORD
|
|
|
Thyroid-associated hormones, Reference interval, Hyperthyroidism, hypothyroidism, Prevalence
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|
|